Effect of trimebutine on contractile responses in skinned ileal smooth muscle

M Nagasaki1, M Itagaki, S Komori

  • 1Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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