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Androgen turnover during marathon running

G A Ponjee1, H A De Rooy, H L Vader

  • 1Diagnostisch Centrum SSDZ, Delft, The Netherlands.

Medicine and Science in Sports and Exercise
|October 1, 1994
PubMed
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Marathon running significantly increases adrenal and gonadal androgens, including testosterone and dehydroepiandrosterone sulfate. Peripheral androgen metabolism also increases, indicated by elevated 3 alpha-diol glucuronide levels after prolonged physical stress.

Area of Science:

  • Endocrinology
  • Sports Medicine
  • Exercise Physiology

Background:

  • Prolonged physical stress, such as marathon running, can significantly impact hormonal balance.
  • Understanding androgen dynamics during intense exercise is crucial for athletes' health and performance.

Purpose of the Study:

  • To investigate the effects of prolonged physical stress from marathon running on peripheral androgen turnover.
  • To analyze changes in key androgenic hormones and their metabolites in athletes before and after a marathon.

Main Methods:

  • Blood samples were collected from 18 athletes 24 hours before and immediately after a competitive marathon.
  • Serum concentrations of cortisol, testosterone (T), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-AdiolG) were measured.

Related Experiment Videos

  • Hormone levels were corrected for hemoconcentration.

    • Main Results:

    • Marathon running led to increased serum cortisol concentrations in all participants.
    • Significant increases (P < 0.01) were observed in serum testosterone (T) and the T-index, indicating higher free testosterone availability.
    • Serum dehydroepiandrosterone sulfate (DHEAS) concentrations rose significantly (P < 0.01), suggesting adrenal cortex stimulation or reduced hepatic clearance.
    • Elevated levels of 3 alpha-AdiolG, a peripheral androgen metabolite, were found in all athletes post-marathon.

    Conclusions:

    • Marathon running results in elevated serum concentrations of both adrenal and gonadal androgens.
    • Increased 3 alpha-AdiolG levels suggest enhanced androgen turnover in peripheral tissues with 5 alpha-reductase activity due to intense physical stress.