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Limb defects after chorionic villus sampling

F J Hsieh1, M K Shyu, B C Sheu

  • 1Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei.

Obstetrics and Gynecology
|January 1, 1995
PubMed
Summary
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Chorionic villus sampling (CVS) is associated with a significantly higher incidence of limb defects, particularly severe types. This study suggests a correlation between the timing of CVS and the severity of these limb abnormalities.

Area of Science:

  • Obstetrics and Gynecology
  • Teratology
  • Prenatal Diagnosis

Background:

  • Chorionic villus sampling (CVS) is a common prenatal diagnostic technique.
  • Potential associations between invasive procedures and adverse fetal outcomes require thorough investigation.

Purpose of the Study:

  • To investigate the association between chorionic villus sampling (CVS) and the occurrence of limb defects.
  • To compare the spectrum and severity of limb defects in CVS-exposed versus the general population.

Main Methods:

  • A survey of 165 obstetric units in Taiwan collected data on limb defect incidence in 1991.
  • Data on limb defects in CVS-exposed pregnancies from September 1990 to June 1992 were also gathered.
  • The Poisson test was used to compare defect rates between exposed and general populations.

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Main Results:

  • Limb defect incidence was significantly higher in CVS-exposed pregnancies (0.294%) compared to the general population (0.032%).
  • Severe limb defects were also significantly more frequent in the CVS-exposed group (0.22%) versus the general population (0.0026%).
  • Reported defects included transverse limb reduction, mid-palm reduction, adactyly/hypodactyly, syndactyly, and oromandibular-limb hypogenesis syndrome.

Conclusions:

  • Chorionic villus sampling (CVS) is linked to an increased incidence of limb defects, especially severe malformations.
  • The spectrum of limb defects observed after CVS appears more severe and specific than in the general population.
  • A potential correlation between the timing of CVS and the severity of limb defects is suggested.