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Tuberculous infertility and in vitro fertilization
S F Marcus1, B Rizk, S Fountain
1Bourn Hall Clinic, Cambridge, United Kingdom.
American Journal of Obstetrics and Gynecology
|December 1, 1994
Summary
In vitro fertilization and embryo transfer (IVF-ET) offers a viable treatment for tuberculous infertility. Successful pregnancy outcomes were linked to a healthy endometrium, highlighting its importance in treatment prognosis.
Area of Science:
- Reproductive Medicine
- Infectious Diseases
- Gynecology
Background:
- Tuberculous infertility poses a significant challenge in reproductive medicine.
- Limited treatment options exist for women with infertility due to tuberculosis.
Purpose of the Study:
- To evaluate the effectiveness of in vitro fertilization and embryo transfer (IVF-ET) for tuberculous infertility.
- To identify factors influencing the success or failure of IVF-ET in these patients.
Main Methods:
- Twenty-two IVF-ET cycles and 9 cryopreserved-thawed embryo transfers were performed in 10 patients.
- Endometrial assessment included ultrasonography, hysteroscopy, biopsy, and Doppler studies.
- Pregnancy outcomes were analyzed in relation to endometrial characteristics.
Main Results:
- Six clinical pregnancies resulted in 3 live births and 1 ongoing pregnancy.
- A significant difference in pregnancy rates was observed based on endometrial status: 42.9% with trophic endometrium versus 0% with atrophic endometrium.
- One ectopic and one spontaneous abortion (at 14 weeks) occurred.
Conclusions:
- In vitro fertilization and embryo transfer represents a realistic treatment avenue for tuberculous infertility.
- Preliminary endometrial assessment is crucial for predicting treatment success in patients with tuberculous infertility.