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[Alien limb behavior associated with Alzheimer's disease]

R Alberca1, I Ferrer, E Marqués

  • 1Servicio de Neurología, Hospital Universitario Virgen del Rocío, Sevilla.

Neurologia (Barcelona, Spain)
|October 1, 1994
PubMed
Summary

This study reports an unusual case of a 48-year-old woman with apraxia, aphasia, and dementia. Neuropathological examination revealed Alzheimer's disease as the sole abnormality, challenging typical presentations.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Alzheimer's disease is a progressive neurodegenerative disorder typically characterized by memory loss and cognitive decline.
  • The classic neuropathological hallmarks include amyloid plaques and neurofibrillary tangles.

Observation:

  • A 48-year-old female presented with a rare clinical syndrome including apraxia, aphasia, dementia, alien limb sign, supranuclear gaze paresis, myoclonus, and right-sided rigidity.
  • Clinical symptoms progressed rapidly, suggesting an atypical neurological condition.

Findings:

  • Frontal lobe biopsy revealed the exclusive presence of typical Alzheimer's disease lesions.
  • No other neuropathological abnormalities were identified, such as those typically seen in frontotemporal dementia or other neurodegenerative diseases.

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Implications:

  • This case highlights the potential for Alzheimer's disease to manifest with an unusual and severe clinical presentation mimicking other neurological disorders.
  • Further research is needed to understand the mechanisms underlying atypical Alzheimer's disease presentations and their diagnostic challenges.