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Unicortical critical size defect of rabbit tibia is larger than 8 mm
M Aaboe1, E M Pinholt, E Hjørting-Hansen
1Department of Oral & Maxillofacial Surgery, School of Dentistry, Faculty of Health Science, University of Copenhagen, Denmark.
Abstract:
The critical-size defect is important as an experimental model to test bone repair materials. Guided tissue regeneration is an established method for tissue regeneration within periodontal surgery. Bony defects covered by a membrane are allowed to be filled by bony tissue. Healing of 8-mm unicortical trephine defects was tested in Copenhagen White rabbit tibia using 3 different membranes. The critical-size defect in Copenhagen White rabbit tibia is larger than 8 mm, because control defects 8 mm in diameter healed spontaneously. However, it is anatomically not possible to create defects larger than 8 mm in an adult Copenhagen White rabbit tibia.