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Related Experiment Videos

Autonomic neuropathies

P A Low1

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905.

Current Opinion in Neurology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Acute autonomic neuropathies exist on a spectrum, from widespread pandysautonomia to Guillain-Barré syndrome. While pure forms are rare, understanding these conditions aids diagnosis and treatment, with some patients showing substantial improvement.

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Area of Science:

  • Neurology
  • Autonomic Nervous System Disorders

Background:

  • Acute autonomic neuropathies present a spectrum of severity and affected systems.
  • Pandysautonomia represents severe sympathetic and parasympathetic failure, while Guillain-Barré syndrome primarily affects the somatic nervous system.
  • Pure autonomic neuropathies are uncommon; most cases involve minor somatic features.

Purpose of the Study:

  • To fill a gap in the clinical description and course of idiopathic autonomic neuropathies.
  • To provide neurologic and autonomic testing endpoints for better characterization.
  • To enhance understanding of autonomic failure, syncope mechanisms, and cerebral vasoregulation.

Main Methods:

  • Clinical description and longitudinal course assessment of idiopathic autonomic neuropathies.

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  • Neurologic and autonomic function testing.
  • Evaluation of neural structure via skin biopsy and laboratory analysis.
  • Frequency domain analysis and cerebral vasoregulation studies.

    • Main Results:

    • Approximately 25-33% of patients experience substantial improvement.
    • Autonomic neuropathy can manifest as pseudo-obstruction and postural tachycardia syndromes.
    • Baroreceptor dysfunction leads to treatable blood pressure lability.
    • Anemia correction can improve orthostatic tolerance.

    Conclusions:

    • Idiopathic autonomic neuropathies are a diverse group of disorders with varying clinical presentations and prognoses.
    • Improved diagnostic tools allow for better quantification of autonomic dysfunction and syncope.
    • Understanding cerebral vasoregulation is crucial for managing autonomic disorders.