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Chemoprevention

P Greenwald1, G Kelloff, C Burch-Whitman

  • 1Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland.

CA: a Cancer Journal for Clinicians
|January 1, 1995
PubMed
Summary
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Chemoprevention offers a promising strategy to prevent invasive cancer by identifying agents that halt or reverse carcinogenesis. This research reviews current efforts in agent identification, screening, and evaluation for early intervention in high-risk patients.

Area of Science:

  • Oncology
  • Preventive Medicine
  • Carcinogenesis Research

Background:

  • Chemoprevention is a key strategy for cancer prevention.
  • Identifying agents that inhibit or reverse carcinogenesis is crucial.
  • Early intervention can prevent invasive and metastatic cancer phases.

Purpose of the Study:

  • To review current chemoprevention research efforts.
  • To highlight promising chemopreventive agents.
  • To discuss screening and evaluation methodologies.

Main Methods:

  • Literature review of chemoprevention research.
  • Analysis of agent identification strategies.
  • Summary of preclinical and clinical evaluation data.

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Main Results:

  • Chemoprevention research is advancing with promising agent identification.
  • Screening and evaluation methods are being refined.
  • Potential for early intervention in high-risk populations is increasing.

Conclusions:

  • Chemoprevention holds significant promise for reducing cancer incidence.
  • Continued research is vital for developing effective early intervention strategies.
  • This review consolidates current knowledge and future directions in the field.