[The correlation between occurrence of intracranial germ cell tumors and p53 tumor suppressor gene mutations]
1Department of Pathology, Capital Institute of Pediatrics, Beijing.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|August 1, 1994
Abstract:
Using PCR-SSCP molecular biological techniques and sequencing analysis, an investigation on intracranial germ cell tumors for a correlation between the p53 tumor suppressor gene mutations and the occurrence of these tumors was performed. The results were as follows: 1. The p53 gene mutations were closely related with the development of intracranial germ cell tumors; 2. Among the germ cell tumors, different types of tumors had different p53 tumor gene mutations.
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