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Filariasis

H B Routh1, K R Bhowmik

  • 1Department of Dermatology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.

Dermatologic Clinics
|October 1, 1994
PubMed
Summary

Filariasis, a tropical disease, can progress to elephantiasis in 10% of cases. This lymphatic obstruction causes severe swelling and deformity, but is preventable with vector control and early treatment.

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Area of Science:

  • Tropical medicine
  • Infectious diseases
  • Public health

Background:

  • Filariasis affects numerous tropical and subtropical regions globally.
  • A significant complication, elephantiasis, impacts approximately 10% of filariasis patients.
  • Elephantiasis results from lymphatic system obstruction, leading to severe swelling and ulceration, primarily in the legs.

Purpose of the Study:

  • To highlight the progression of filariasis to elephantiasis.
  • To describe the clinical manifestations and impact of elephantiasis.
  • To emphasize the preventable nature of the condition.

Main Methods:

  • Review of filariasis and elephantiasis pathophysiology.
  • Analysis of epidemiological data on filariasis prevalence.
  • Summary of current prevention and treatment strategies.

Main Results:

  • Filariasis is endemic in many tropical and subtropical areas.
  • Elephantiasis, the end-stage of filariasis, involves lymphatic obstruction causing significant limb swelling and deformity.
  • Impaired mobility and function are common consequences of elephantiasis.

Conclusions:

  • Filariasis poses a substantial public health challenge in endemic regions.
  • Elephantiasis represents a severe, debilitating outcome of untreated or advanced filariasis.
  • Effective prevention and management strategies, including vector control and prompt drug therapy, are crucial for mitigating the impact of filariasis and preventing elephantiasis.

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