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In vitro fertilization and oocyte donation in women 45 years of age and older
1In Vitro Fertilization-Embryo Transfer Units, Tel Aviv Sourasky Medical Center, Israel.
Objective:
To assess the reproductive potential in women > or = 45 years of age.
Design:
Retrospective analysis.
Setting:
In vitro fertilization-embryo transfer unit, standard IVF and oocyte donation programs.
Patients:
One hundred twenty-seven patients > or = 45 years old who applied for treatment of infertility.
Intervention:
Thirty-one patients underwent 52 treatment cycles in standard IVF. Ninety-six patients underwent 220 oocyte donation cycles.
Results:
Of the 52 standard IVF cycles, oocytes were retrieved successfully in only 32. Of these, fertilization and ET were performed in 21 cycles. None of these treatment cycles resulted in a clinical pregnancy. Of the 220 oocyte donation cycles, fertilization and ET were accomplished in 189 cycles. These resulted in 33 (17.5% per transfer) clinical pregnancies.
Conclusions:
These results suggest that oocyte donation may extend the reproductive potential in women > or = 45 years old when little hope is offered by standard IVF.