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Rapid disruption of epithelial barrier function by Salmonella typhimurium is associated with structural modification
M A Jepson1, C B Collares-Buzato, M A Clark
1Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, United Kingdom.
Infection and Immunity
|January 1, 1995
Abstract:
Short-term infection of MDCK II monolayers with Salmonella typhimurium SL1344 caused a progressive decrease in transepithelial electrical resistance concomitant with decreased cation permselectivity and increased paracellular inulin flux. Cytochemical staining of F-actin, E-cadherin, and ZO-1 revealed the concentration of each junctional protein in invaded cells as a result of contraction at their apical poles and resultant distortion of adjacent uninvaded cells.