Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ciliary neurotrophic factor: a review

P M Richardson1

  • 1Division of Neurosurgery, McGill University, Montreal General Hospital, Canada.

Pharmacology & Therapeutics
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor Necrosis Factor-α Induces Monocyte Chemoattractant Protein-1 mRNA in a Schwann Cell Line.

Annals of the New York Academy of Sciences·2017
Same author

NMR T1 relaxation time measurements and calculations with translational and rotational components for liquid electrolytes containing LiBF4 and propylene carbonate.

The Journal of chemical physics·2013
Same author

Posttraumatic activity of signal pathways of nuclear factor κB in mature sensory neurons.

Bulletin of experimental biology and medicine·2011
Same author

Two cytokine signaling molecules co-operate to promote axonal transport and growth.

Experimental neurology·2010
Same author

Neuroscience. Nuclear power for axonal growth.

Science (New York, N.Y.)·2009
Same author

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same journal

C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Pharmacology & therapeutics·2026
Same journal

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation.

Pharmacology & therapeutics·2026
Same journal

Glymphatic-meningeal lymphatic dysfunction in epilepsy: novel mechanistic insights and therapeutic avenues.

Pharmacology & therapeutics·2026
Same journal

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026
Same journal

A-type potassium channels in pain signaling: Fundamental mechanisms and pathophysiological roles.

Pharmacology & therapeutics·2026
Same journal

GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implications.

Pharmacology & therapeutics·2026
See all related articles

Ciliary neurotrophic factor (CNTF) supports neuron survival and development in the nervous system. Its precise functions and release mechanisms from glial cells require further investigation.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Ciliary neurotrophic factor (CNTF) is a protein with structural similarities to leukemia inhibitory factor (LIF) and interleukin-6.
  • CNTF shares receptor components (LIF beta receptor, gp130) with LIF and interleukin-6.
  • Schwann cells and astrocytes are primary producers of CNTF, but release mechanisms and quantities are unknown.

Purpose of the Study:

  • To elucidate the functions of Ciliary neurotrophic factor (CNTF) in the nervous system.
  • To investigate the in vitro and in vivo effects of CNTF on neuronal cells.
  • To understand the role of CNTF in neuronal development and survival.

Main Methods:

  • In vitro studies assessing CNTF effects on neuronal survival, neurite outgrowth, and precursor cell division.

Related Experiment Videos

  • In vivo studies examining CNTF's neuroprotective effects after axotomy.
  • Analysis of CNTF receptor complex composition.

    • Main Results:

    • CNTF supports survival of peripheral and central nervous system neurons in vitro.
    • CNTF promotes neurite outgrowth and cholinergic differentiation in sympathetic neurons.
    • CNTF prevents axotomy-induced neuronal death in vivo.
    • CNTF also affects neuronal precursor cell division and responds to several cell lines.

    Conclusions:

    • CNTF exhibits significant neurotrophic and neuroprotective properties.
    • The precise in vivo functions of CNTF in nervous system development and maintenance remain to be fully elucidated.
    • Further research is needed to understand CNTF release mechanisms from glial cells.