Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testosterone levels during systemic and inhaled corticosteroid therapy

D Morrison1, S Capewell, S P Reynolds

  • 1Department of Chest Diseases, Tenovus Institute, University of Wales College of Medicine, Cardiff, U.K.

Respiratory Medicine
|October 1, 1994
PubMed
Summary

Long-term oral corticosteroid therapy significantly lowers testosterone levels in men. High-dose inhaled corticosteroids showed a non-significant reduction, suggesting alternative pathways for bone metabolism issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Live birth and maternity outcome in childhood and adolescent cancer survivors under 18 years at diagnosis: a 40-year population-based cohort study.

British journal of cancer·2024
Same author

Exploring the <i>raison d'etre</i> behind metric selection in network analysis: a systematic review.

Applied network science·2022
Same author

Erratum: Genomes reveal genetic diversity of Piscine orthoreovirus in farmed and free-ranging salmonids from Canada and USA.

Virus evolution·2021
Same author

Genomes reveal genetic diversity of Piscine orthoreovirus in farmed and free-ranging salmonids from Canada and USA.

Virus evolution·2020
Same author

Tracking Staphylococcus aureus in the intensive care unit using whole-genome sequencing.

The Journal of hospital infection·2019
Same author

Characteristics and outcomes of lung cancer patients after intensive care admission.

Journal of the Intensive Care Society·2017

Area of Science:

  • Endocrinology
  • Pulmonology
  • Bone Metabolism

Background:

  • Testosterone is crucial for bone formation and is linked to hypogonadism and osteoporosis.
  • Long-term oral corticosteroid use is known to reduce testosterone levels.
  • The impact of inhaled corticosteroids on testosterone is not well understood.

Purpose of the Study:

  • To investigate the effect of inhaled corticosteroid therapy on testosterone levels in male patients with respiratory disease.
  • To compare testosterone levels in patients on oral corticosteroids, inhaled corticosteroids, and healthy controls.

Main Methods:

  • Measured testosterone, luteinizing hormone, follicle stimulating hormone, and sex hormone binding globulin in 35 male patients and 19 controls.
  • Grouped patients based on steroid therapy: oral prednisolone, low-dose inhaled beclomethasone, high-dose inhaled beclomethasone.

Related Experiment Videos

Main Results:

  • Testosterone levels were 33% lower in men on long-term oral prednisolone compared to controls.
  • No significant reduction in testosterone was observed in patients on low-dose (200-800 µg/day) or high-dose (1500-2250 µg/day) inhaled beclomethasone.
  • Hormone levels (LH, FSH, SHBG) were similar across all groups.

Conclusions:

  • Long-term systemic corticosteroid therapy, particularly oral prednisolone, reduces testosterone levels.
  • Inhaled corticosteroids demonstrated a minimal, non-significant impact on testosterone levels in this study.
  • Further research is needed to explore other mechanisms contributing to disordered bone metabolism in patients using inhaled corticosteroids.