Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medulloblastoma

C D Katsetos1, P C Burger

  • 1Department of Pathology, Hahnemann University, Philadelphia, PA 19102-1192.

Seminars in Diagnostic Pathology
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Medulloblastomas, a type of central nervous system embryonal tumor, may originate from two distinct cerebellar cell sources. Immunoreactivity patterns suggest different origins for classic and desmoplastic medulloblastomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.

Oncogene·2016
Same author

Histopathological observations in the brains of children exposed to inhalational anesthetic agents: a retrospective autopsy-based study.

Minerva anestesiologica·2015
Same author

Progressive multifocal leukoencephalopathy in a patient without immunodeficiency.

Neurology·2011
Same author

Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.

Neuropathology and applied neurobiology·2006
Same author

[The role played by calcium in neuronal injury following neonatal hypoxia or convulsions].

Revista de neurologia·2006
Same author

[Cerebrovascular disorders in preterm neonates].

Revista de neurologia·2006
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Area of Science:

  • Neuro-oncology
  • Developmental neurobiology
  • Histopathology

Background:

  • The histogenetic approach is widely accepted for classifying central nervous system embryonal tumors.
  • Medulloblastoma, a neuroblastic neoplasm, is traceable to cerebellar embryogenesis and exhibits neuronal differentiation.
  • Some medulloblastomas contain ganglion cells, and glial differentiation is occasionally observed.

Purpose of the Study:

  • To investigate the potential origins of medulloblastomas using a histogenetic approach.
  • To differentiate between classic and desmoplastic medulloblastomas based on cellular origins.
  • To explore the nature of ganglion cells and glial differentiation in medulloblastomas.

Main Methods:

  • Utilizing differential immunoreactivity patterns for calbindin-D28k and class III beta-tubulin.

Related Experiment Videos

  • Analyzing antigenic determinants associated with neuronal differentiation.
  • Histologic examination of medulloblastoma subtypes.

    • Main Results:

    • Immunoreactivity suggests distinct subsets of medulloblastomas may arise from the ventricular matrix (VM) or the external granule layer (EGL).
    • Classic medulloblastomas may originate from the VM, while desmoplastic medulloblastomas might arise from the EGL.
    • Ganglion cell origin in medulloblastomas remains unclear, potentially being neoplastic or dysplastic; glial differentiation may involve VM glial precursors or stromal induction.

    Conclusions:

    • Medulloblastomas likely originate from distinct neuroblast populations within the cerebellum.
    • The VM and EGL are proposed as potential sources for classic and desmoplastic medulloblastomas, respectively.
    • Further research is needed to clarify the exact origin and nature of ganglion cells and glial components in medulloblastomas.