Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombolytic therapy in experimental embolic stroke

K Overgaard1

  • 1Department of Neurology, University Hospital of Copenhagen, Rigshospitalet, Denmark.

Cerebrovascular and Brain Metabolism Reviews
|January 1, 1994
PubMed
Summary

Early thrombolytic therapy in animal models significantly reduces brain damage and mortality in embolic stroke by promoting reperfusion. The extent of damage depends on clot characteristics and reperfusion timing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is curvature of the force-velocity relationship affected by oxygen availability? Evidence from studies in ex vivo and in situ rat muscles.

Pflugers Archiv : European journal of physiology·2020
Same author

Effects of manipulating tetanic calcium on the curvature of the force-velocity relationship in isolated rat soleus muscles.

Acta physiologica (Oxford, England)·2017
Same author

Electrode placement in bioimpedance spectroscopy: evaluation of alternative positioning of electrodes when measuring relative dehydration in athletes.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
Same author

Effects of sprint interval training on VO2max and aerobic exercise performance: A systematic review and meta-analysis.

Scandinavian journal of medicine & science in sports·2013
Same author

Muscle fiber size increases following resistance training in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2010
Same author

Studies on the excretion of penicillin through the kidneys and the mechanism of this process.

Acta pharmacologica et toxicologica·2010

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Thrombolytic therapy is established for heart attacks but less understood for acute ischemic stroke.
  • Rapid arterial recanalization is key to minimizing neuronal damage in cerebral infarction.
  • Pathophysiology of reperfusion in stroke thrombolysis requires further investigation.

Purpose of the Study:

  • To review studies on thrombolysis in experimental embolic stroke models.
  • To investigate the impact of recombinant tissue-type plasminogen activator (rt-PA) on reperfusion and brain damage.
  • To elucidate the relationship between reperfusion timing, clot characteristics, and stroke outcomes.

Main Methods:

  • Utilized animal models of embolic stroke induced by intracarotid blood clots.
  • Assessed vascular occlusion via angiography and cerebral blood flow measurements.
  • Administered rt-PA at varying time points post-occlusion and evaluated reperfusion, cellular function, and brain damage.

Main Results:

  • Early thrombolytic therapy in animal models improved reperfusion, reduced brain damage, clinical deficits, and mortality.
  • Delayed or incomplete reperfusion is the primary cause of cerebral infarction, with spasms playing a minor role.
  • Brain damage extent correlates with the delay from ischemia onset to reperfusion.
  • Cerebral stunning occurs with very early reperfusion, causing temporary neuronal dysfunction.
  • Clot characteristics (volume, composition) and number influence brain damage severity.
  • Recanalization success depends on clot red cell content, volume, fibrin density, and composition.

Conclusions:

  • Early reperfusion via thrombolysis is critical for limiting infarct size and edema in embolic stroke.
  • Neuroprotective agents or hypothermia can further reduce infarct-limiting effects, enhancing thrombolytic therapy outcomes.

Related Experiment Videos