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Gas chromatography-mass spectrometry determination of etodolac in human plasma following single epicutaneous
C Giachetti1, A Assandri, G Zanolo
1Istituto di Ricerche Biomediche A. Marxer, RBM S.p.A., Ivrea (TO), Italy.
Biomedical Chromatography : BMC
|July 1, 1994
Abstract:
A highly sensitive gas chromatographic-mass spectrometric method for the determination of etodolac acid, as methyl ester, in plasma was developed. The feasibility and specificity of the method was ascertained monitoring the concentration levels in plasma samples collected from 12 male healthy volunteers given epicutaneously 5 g of 10% etodolac gel formulation.