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[The role of serotonin in the regulation of the immune response]

E Jahnová1

  • 1Oddelenie klinickej imunológie, Ustavu preventívnej a klinickej medicíny v Bratislave.

Bratislavske Lekarske Listy
|April 1, 1994
PubMed

The author presents in her study the currently known serotonin effects on the immunity system, and the possibility of medicamentous utilization of agonists and antagonists of serotonin receptors in order to elucidate the effect of the 5-HT immunomodulating mechanism. 5-HT affects the antibody formation in sense of its reduction, the formation being evoked by antigenic stimuli. The mechanism involved however, is not entirely clear. The particular receptor being co-responsible in DNA synthesis inhibition is 5-TH1. The reduction of MHC-antigens expressiveness, which takes place due to serotonin, is intermediated by the classical 5-HT2 receptor. The procedure takes place in cooperation with 5-HT1A receptor. The serotonin induced augmented NK cells cytotoxicity is specifically mediated by 5-HT1 receptor. The participation of serotonin is assumed in pathogenesis of various diseases, there is however, relatively little knowledge about its effect on immunity system.

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