Related Experiment Video
Updated: Aug 13, 2026
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
Published on: June 22, 2015
7-OH-DPAT produces place conditioning in rats
1Department of Psychology, Queen's University, Kingston, Ontario, Canada.
Abstract:
The rewarding properties of the putative dopamine D3 receptor-selective agonist, 7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4- tetrahydronaphthalene hydrobromide), were investigated using a place conditioning paradigm consisting of three phases: preconditioning (three undrugged exposures to an apparatus consisting of two visually distinct compartments); conditioning (four pairings of one compartment with drug); and test (one undrugged exposure to the same apparatus). Rats received either saline, amphetamine (2.0 mg/kg), or 7-OH-DPAT (0.5, 2.0 or 5.0 mg/kg) during conditioning. Amphetamine and 7-OH-DPAT produced a place preference.
