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Epidemiological correlates of preterm premature rupture of membranes
A Spinillo1, S Nicola, G Piazzi
1Department of Obstetrics and Gynecology, IRCCS Policlinico S. Matteo, University of Pavia, Italy.
Objective:
To study the clinical risk factors for preterm premature rupture of membranes (PROM).
Method:
We conducted a case-control study of 138 patients with PROM between 24 and 35 weeks' gestation and 267 control subjects.
Results:
In stepwise multiple logistic regression models, the population of cases was more likely to be of low social class. Other risk factors for PROM were smoking in pregnancy, 1st or 2nd-3rd trimester hemorrhages, cervical incompetence and a documented cervico-vaginal infection during index pregnancy. First trimester hemorrhage and a documented cervico-vaginal infection during index pregnancy were associated with preterm PROM both in nulliparous and in multiparous women.
Conclusion:
Few potentially remediable risk factors are associated with the occurrence of preterm PROM.