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Updated: Aug 18, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Oxybutynin administration diminishes the high gastric muscular tone associated with bladder reconstruction
C A Sheldon1, D Reeves, A G Lewis
1Division of Urology, Children's Hospital Medical Center, University of Cincinnati, Ohio.
Abstract:
Oxybutynin has a proved role in correcting uninhibited detrusor contractions in the intact and the bowel augmented bladder. Beneficial responses to oxybutynin have also been noted after gastrocystoplasty. It has been questioned whether this response reflects a selective effect on the bladder segment or whether there is an additional effect on the gastric patch musculature. We report a case of improved function of a previously poorly complaint gastric neobladder caused by oxybutynin, thereby demonstrating a direct action on gastric smooth muscle.
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