Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is interstitial cystitis an infectious disease?

J W Warren1

  • 1Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.

Medical Hypotheses
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An unusual case of Hodgkin's disease; second report.

Archives of ophthalmology (Chicago, Ill. : 1929)·2010
Same author

ON THE PRESENCE OF THE AMYLOLYTIC FERMENT AND ITS ZYMOGEN IN THE SALIVARY GLANDS.

The Journal of experimental medicine·2009
Same author

ON THE PRESENCE OF A MILK-CURDLING FERMENT (PEXIN) IN THE GASTRIC MUCOUS MEMBRANE OF VERTEBRATES : A SUMMARY OF EXPERIMENTS MADE IN THE BIOLOGICAL LABORATORY OF BRYN MAWR COLLEGE BY CAROLINE W. LATIMER, M. D., ANNE C. COLEMAN, B. A., AND ROSALIE A. FURMAN, B. A.

The Journal of experimental medicine·2009
Same author

Using protein-based motifs to stabilize peptides.

The journal of peptide research : official journal of the American Peptide Society·2003
Same author

Is interstitial cystitis an infectious disease?

International journal of antimicrobial agents·2002
Same author

Practice guidelines for the treatment of uncomplicated cystitis.

Current urology reports·2002

Interstitial cystitis (IC) may stem from an unidentified infectious agent, not solely autoimmune or permeability issues. Further investigation using advanced culture techniques on bladder tissue is recommended to rule out chronic infection.

Area of Science:

  • Urology
  • Infectious Diseases
  • Pathogenesis Research

Background:

  • Interstitial cystitis (IC) presents with chronic urinary frequency, urgency, and bladder pain.
  • Diagnosis via cystoscopy reveals petechial hemorrhages or ulcers.
  • Current theories attribute IC to autoimmune factors or increased bladder mucosal permeability, with unknown etiology.

Purpose of the Study:

  • To explore the possibility that an infectious agent has not been adequately ruled out as a cause of Interstitial Cystitis (IC).
  • To propose advanced diagnostic methods for identifying potential infectious agents in IC.
  • To integrate infectious disease hypotheses into existing IC pathogenesis theories.

Main Methods:

  • Review of existing literature on IC etiology and diagnostic limitations.

Related Experiment Videos

  • Proposal for specialized culture and non-culture techniques, including polymerase chain reaction (PCR), applied to bladder epithelium.
  • Comparison of IC pathogenesis with other chronic conditions like Helicobacter pylori-associated gastritis.

    • Main Results:

    • No infectious agent has been definitively identified in Interstitial Cystitis (IC) despite extensive searches.
    • The characteristics of IC align with those of chronic infections.
    • Advanced diagnostic methods on bladder tissue, not just urine, are necessary to exclude infection.

    Conclusions:

    • An infectious etiology for Interstitial Cystitis (IC) remains a plausible, yet unproven, hypothesis.
    • Infection could potentially coexist with or explain autoimmune and permeability theories of IC.
    • Further research employing novel techniques is crucial to definitively rule out or identify infectious causes of IC.