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Determination of split renal function from gamma camera renography: a study of three methods
M Moonen1, L Jacobsson, G Granerus
1Department of Clinical Physiology, Sahlgren's Hospital, University of Göteborg, Sweden.
Nuclear Medicine Communications
|September 1, 1994
Summary
The uptake index and slope methods accurately calculate split kidney function using 99Tcm-DTPA renography. The uptake index method also reveals abnormal intrarenal blood volume in kidney tumor patients.
Area of Science:
- Nuclear Medicine
- Renal Physiology
- Diagnostic Imaging
Background:
- Assessing split kidney function is crucial for diagnosing and managing renal diseases.
- Gamma camera renography with 99Tcm-DTPA is a common diagnostic tool.
- Different calculation methods exist, but their accuracy and clinical utility vary.
Purpose of the Study:
- To evaluate and compare the accuracy and reproducibility of three methods for calculating split kidney function: integral, slope, and uptake index.
- To assess the clinical utility of the uptake index method in identifying abnormalities in intrarenal blood volume, particularly in patients with kidney tumors.
Main Methods:
- Three methods (integral, slope, uptake index) were used to calculate split kidney function from 99Tcm-DTPA renography.
- Reproducibility was assessed using the coefficient of variation.
- Accuracy was determined by comparing calculated glomerular filtration rate (GFR) with 51Cr-EDTA clearance post-nephrectomy.
- The uptake index ratio (alpha/UI)SR was compared between patients with kidney tumors and a control group.
Main Results:
- All three methods demonstrated very good reproducibility (2-4% coefficient of variation).
- The slope and uptake index methods showed high accuracy (0.9-2.0 ml/min) compared to 51Cr-EDTA clearance, while the integral method had reduced accuracy (4.6 ml/min).
- The uptake index ratio was significantly higher and more variable in kidney tumor patients, suggesting abnormal intrarenal blood volume.
- Correlation between methods was good in controls but deteriorated in tumor patients.
Conclusions:
- The slope and uptake index methods are accurate and reproducible for split kidney function assessment using 99Tcm-DTPA renography.
- The uptake index method provides additional diagnostic information regarding intrarenal blood volume, differentiating tumor patients from controls.
- These findings support the clinical utility of the uptake index method in evaluating renal function and detecting abnormalities in kidney tumors.