[Arterial hypertension refractory to hypotensive treatment]

Lack of normalization of arterial pressure in spite of treatment of hypertension is most frequently caused by irregular and incomplete taking of hypotensive drugs or by erroneous medical instructions (drug interactions). "True" resistance to 3 simultaneously administered hypotensive drugs in optimal doses may be caused by secondary hypertension. In a part of cases of refractory essential hypertension an increased insulin concentration is found. In the paper the importance is discussed of "resistance" to insulin in the development of hypertension.