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Updated: Aug 12, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Resolution of left atrial spontaneous echocardiographic contrast after percutaneous mitral valvuloplasty:
D Y Leung1, I W Black, G B Cranney
1Department of Cardiovascular Medicine, Prince Henry Hospital, Sydney, Australia.
Insights
Percutaneous transseptal mitral valvuloplasty (PTMV) often resolves left atrial spontaneous echocardiographic contrast (SEC), a marker of stroke risk in mitral stenosis patients. This resolution, linked to improved valve area, suggests PTMV may reduce thromboembolic events.
Area of Science:
- Cardiology
- Echocardiography
- Interventional Cardiology
Background:
- Left atrial spontaneous echocardiographic contrast (SEC) is a significant indicator of thromboembolic risk in patients diagnosed with mitral stenosis.
- Understanding factors influencing SEC and its resolution is crucial for managing patient outcomes.
Purpose of the Study:
- To investigate the impact of percutaneous transseptal mitral valvuloplasty (PTMV) on left atrial spontaneous echocardiographic contrast (SEC) in patients with mitral stenosis.
- To identify predictors for the resolution of SEC following PTMV.
Main Methods:
- Transesophageal echocardiography was conducted on 88 mitral stenosis patients one day before and three months after PTMV.
- Echocardiographic parameters, including SEC presence, valve area, and mitral regurgitation, were assessed and analyzed.
Main Results:
- Before PTMV, 74% of patients exhibited SEC, associated with smaller valve area, older age, and atrial fibrillation.
- PTMV significantly increased valve area. SEC resolved in 37 patients and persisted in 28 (32%) at three months.
- A relative increase in valve area post-PTMV was the sole significant predictor for SEC resolution on multivariate analysis.
Conclusions:
- PTMV effectively reduces left atrial spontaneous echocardiographic contrast in a majority of mitral stenosis patients.
- The resolution of SEC following PTMV holds potential implications for decreasing thromboembolic risk in this patient cohort.
Abstract:
Left atrial spontaneous echocardiographic contrast (SEC) is an important marker of increased thromboembolic risk in patients with mitral stenosis. To evaluate the effect of percutaneous transseptal mitral valvuloplasty (PTMV) on SEC, we performed transesophageal echocardiography 1 day before and 3 months after PTMV on 88 consecutive patients. SEC was present in 65 (74%) patients before PTMV and was associated with absence of moderate or severe mitral regurgitation (p = 0.01), a smaller valve area (p = 0.02), an older age (p = 0.04), and atrial fibrillation (p = 0.05). At 3 months, PTMV resulted in a mean absolute and relative increase in valve area of 0.54 +/- 0.36 cm2 and 53% +/- 43%, respectively. SEC resolved in 37 patients but persisted in 28 (32%) patients at the 3-month study. The absolute and relative increase of valve area and worsened mitral regurgitation after PTMV were predictors of resolution of SEC, with the relative increase in valve area being the only significant predictor on multivariate analysis. PTMV frequently results in resolution of SEC, which may have important implications in reducing the thromboembolic risk in these patients.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation III: Medical Management
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management

