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Scedosporium prolificans sclerokeratitis
L J Sullivan1, G Snibson, C Joseph
1University of Melbourne Department of Ophthalmology, Royal Victorian Eye and Ear Hospital.
Australian and New Zealand Journal of Ophthalmology
|August 1, 1994
Summary
Scedosporium prolificans sclerokeratitis, a rare fungal infection, showed poor response to antifungal medications. Early surgical intervention is crucial for successful treatment of this Scedosporium prolificans infection.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Scedosporium prolificans, a fungus, was identified as a human pathogen in 1984.
- It has been linked to metastatic endophthalmitis and sclerokeratitis.
Observation:
- A case of Scedosporium prolificans sclerokeratitis is presented.
- This occurred after pterygium surgery with beta-irradiation, leading to scleral necrosis.
Findings:
- Medical treatments including topical natamycin, amphotericin B, and systemic itraconazole/ketoconazole were ineffective.
- Enucleation was necessary for microbiological cure, with pathological correlation provided.
Implications:
- Scedosporium prolificans infections frequently exhibit resistance to medical therapies.
- Prompt surgical intervention is recommended for culture-proven Scedosporium prolificans scleritis.