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Related Experiment Videos

Interleukin 2-induced increase of vascular permeability without decrease of the intravascular albumin pool

B K Ballmer-Weber1, R Dummer, E Küng

  • 1Department of Dermatology, University of Zurich, Switzerland.

British Journal of Cancer
|January 1, 1995
PubMed
Summary
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Interleukin 2 (IL-2) increases vascular permeability in humans, leading to greater albumin leakage from blood vessels. However, the body

Area of Science:

  • Immunology
  • Oncology
  • Physiology

Background:

  • Interleukin 2 (IL-2) has demonstrated anti-tumour properties.
  • High-dose IL-2 therapy is associated with severe side effects, including pulmonary edema and systemic vascular leak.
  • The precise mechanisms underlying IL-2-mediated transvascular fluid and protein loss in humans remain unclear.

Purpose of the Study:

  • To investigate the impact of IL-2 on vascular permeability in cancer patients.
  • To quantify the transcapillary escape rate (TER) of albumin as an indicator of vascular permeability.
  • To explore the relationship between IL-2 administration and changes in albumin flux.

Main Methods:

  • Ten melanoma patients pretreated with interferon alpha (IFN-alpha) were enrolled.

Related Experiment Videos

  • The transcapillary escape rate (TER) of albumin was measured using [125I]albumin before and after IL-2 injections.
  • Plasma levels of IL-2 and IL-6 were monitored.

    • Main Results:

    • TER of albumin significantly increased post-IL-2 administration (from 9.4 ± 2.7% h-1 to 14.9 ± 3.3% h-1, P < 0.001).
    • Absolute albumin outflux (Jalb) also significantly rose (from 159 ± 28 mg kg-1 h-1 to 261 ± 44 mg kg-1 h-1, P < 0.001).
    • Intravascular albumin pool remained stable, and IL-2 and IL-6 levels increased post-administration.

    Conclusions:

    • IL-2 administration demonstrably increases vascular permeability in humans.
    • Despite increased albumin leakage, the intravascular albumin pool is maintained, suggesting compensatory mechanisms like lymphatic return.
    • These findings provide insights into the side effects of IL-2 therapy and potential management strategies.