Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Luteal phase hyperprolactinemia

R J Falk1, L Anderson

  • 1Division of Reproductive Endocrinology and Infertility, Columbia Hospital for Women Medical Center, Washington, D.C.

International Journal of Fertility and Menopausal Studies
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Entomological study of Phlebotomine Sand flies in Maceió (Brazil): 2011-2020 analysis.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Impact of maternal body mass index (BMI) and the challenges of fetal echocardiography.

Public health·2024
Same author

Capacity building to address antimicrobial resistance in remote Australia: The inaugural HOT NORTH Antimicrobial Academy.

Infection, disease & health·2024
Same author

Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia.

Gynecologic oncology reports·2024
Same author

Betaproteobacteria are a key component of surface water biofilters that maintain sustained manganese removal in response to fluctuations in influent water temperature.

Water research·2023
Same author

Squamous cell carcinoma differentiation at progression as a resistance mechanism in metastatic non-small cell lung carcinoma harbouring a targetable mutation.

Pathology·2022
Same journal

Effect of sperm-agglutinating antibodies on sperm capacitation and acrosome reaction.

International journal of fertility and menopausal studies·1996
Same journal

A comparative study of the effects of an estradiol-releasing vaginal ring combined with an oral gestagen versus transdermal estrogen combined with a levonorgestrel-releasing IUD: clinical findings and endometrial response.

International journal of fertility and menopausal studies·1996
Same journal

The successful use of hyperstimulated washed therapeutic donor insemination after standard therapeutic donor insemination has failed.

International journal of fertility and menopausal studies·1996
Same journal

Effect of oral and transdermal hormone replacement therapy on lipid profile and Lp(a) level in menopausal women with hypercholesterolemia.

International journal of fertility and menopausal studies·1996
Same journal

Selective follicular reduction: what to do with the oocytes?

International journal of fertility and menopausal studies·1996
Same journal

The mind-body connection--anxiety, panic, mood and compulsion.

International journal of fertility and menopausal studies·1996
See all related articles

Sporadic hyperprolactinemia (elevated prolactin) in the luteal phase is common in infertile women. This condition shows an abnormal response to TRH stimulation, but normal progesterone levels suggest unclear pathological significance.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Research
  • Hormonal Imbalances

Background:

  • Luteal phase defects can impact fertility.
  • Hyperprolactinemia is typically associated with infertility.
  • The role of transient prolactin elevations in the luteal phase is not well understood.

Purpose of the Study:

  • To determine the incidence of luteal-phase hyperprolactinemia (LPH) in normoprolactinemic women.
  • To investigate the association between sporadic LPH and progesterone deficiency.
  • To explore the physiological basis of sporadic LPH using thyrotropin-releasing hormone (TRH) challenge tests.

Main Methods:

  • Prospective study of 133 infertile, ovulatory women with normal baseline prolactin.
  • Luteal phase serum prolactin and progesterone levels were measured.

Related Experiment Videos

  • TRH stimulation tests were performed in women with repetitive LPH and in normoprolactinemic controls.

    • Main Results:

    • 36% of women experienced sporadic LPH, with 25% showing repetitive elevations.
    • Women with repetitive LPH had an exaggerated initial prolactin response to TRH, followed by a rapid decline.
    • Luteal phase progesterone levels were normal in women with LPH.

    Conclusions:

    • Sporadic LPH is a frequent finding in infertile women.
    • Repetitive LPH demonstrates an abnormal physiological response to TRH stimulation.
    • Despite abnormal TRH response, normal luteal phase progesterone raises questions about the clinical significance of LPH in infertility.