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Corpus cavernosal relaxation in impotent men

R S Pickard1, P King, M A Zar

  • 1Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK.

British Journal of Urology
|October 1, 1994
PubMed
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Smooth muscle contractility and nerve-mediated relaxation are impaired in men with vasculogenic impotence, affecting penile function. These functional deficits in corpus cavernosum tissue contribute to erectile dysfunction and may explain poor surgical outcomes.

Area of Science:

  • Urology
  • Andrology
  • Physiology

Background:

  • Vasculogenic impotence, characterized by abnormal penile hemodynamics, is a common cause of erectile dysfunction.
  • Understanding the underlying smooth muscle and neurogenic mechanisms is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the functional responsiveness of corpus cavernosum smooth muscle in men with vasculogenic impotence.
  • To compare these responses with those in men with non-vasculogenic impotence and a control group.

Main Methods:

  • Corpus cavernosum biopsies were obtained from 63 men, including controls, those with vasculogenic impotence (arterial, venous, or mixed), and those with non-vasculogenic impotence.
  • Smooth muscle contractile and relaxant responses were measured in tissue strips.

Related Experiment Videos

  • Morphological assessment included histology and immunocytochemistry for nerve density.

    • Main Results:

    • Marked impairment of nerve-evoked relaxation was observed in men with venous or mixed arterial/venous vasculogenic impotence.
    • Decreased contractile response to alpha-adrenoceptor stimulation was noted in all vasculogenic impotence groups.
    • Responses to papaverine and sodium nitroprusside were similar to controls, and smooth muscle content and nerve density were comparable.

    Conclusions:

    • Functional impairment of smooth muscle contractility and neurogenic relaxation occurs in the corpus cavernosum of men with vasculogenic impotence.
    • Altered smooth muscle responsiveness is a significant factor in the etiology of impotence.
    • These findings may explain the suboptimal outcomes of vascular surgery for erectile dysfunction.