Microalbumin excretion in patients with positive exercise electrocardiogram tests
R C Horton1, P Gosling, C N Reeves
1Cardiology Department, Selly Oak Hospital, Birmingham, U.K.
European Heart Journal
|October 1, 1994
Summary
Exercise-induced myocardial ischemia is linked to higher urinary microalbumin excretion. This finding suggests microalbuminuria may indicate cardiac stress during exercise tests.
Area of Science:
- Cardiology
- Nephrology
- Exercise Physiology
Background:
- Myocardial infarction (MI) affects cardiac function.
- Exercise electrocardiogram (ECG) testing assesses cardiac stress.
- Urinary microalbumin excretion (UAE) can indicate endothelial dysfunction.
Purpose of the Study:
- To investigate the relationship between exercise-induced myocardial ischemia and UAE.
- To determine if UAE changes post-exercise in individuals with positive vs. negative ECG tests.
Main Methods:
- 33 subjects (20 with prior MI, 13 controls) underwent exercise ECG testing.
- Urinary albumin-to-creatinine ratio (ACR) measured at rest and 30, 60 min post-exercise.
- ACR compared between groups with positive, negative, and anomalous ECG results.
Main Results:
- Subjects with positive exercise ECGs showed a significant increase in median ACR post-exercise (rest: 1.0; 30 min: 2.0 mg/mmol).
- Subjects with negative exercise ECGs had no significant change in median ACR (rest: 0.85; 30 min: 1.80 mg/mmol).
- Anomalous ECG results were also assessed for ACR changes.
Conclusions:
- Exercise-induced myocardial ischemia is associated with elevated urinary microalbumin excretion.
- Increased UAE following exercise may serve as a potential biomarker for myocardial ischemia.
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