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Meta-analysis of systemic anti-fibrinolytics in traumatic hyphaema
G W Aylward1, I S Dunlop, B C Little
1Moorfields Eye Hospital, London, UK.
Eye (London, England)
|January 1, 1994
Summary
Systemic anti-fibrinolytics reduce secondary hemorrhage in traumatic hyphaema. However, these treatments do not improve final visual acuity in patients. Further research may be needed for visual outcomes.
Area of Science:
- Ophthalmology
- Trauma Care
- Pharmacology
Background:
- Traumatic hyphaema is a common ocular injury.
- Secondary hemorrhage is a significant complication of traumatic hyphaema.
- Systemic anti-fibrinolytics are used to manage bleeding disorders.
Purpose of the Study:
- To evaluate the efficacy of systemic anti-fibrinolytics in reducing secondary hemorrhage in traumatic hyphaema.
- To assess the impact of systemic anti-fibrinolytics on final visual acuity after traumatic hyphaema.
Main Methods:
- Meta-analysis of randomized controlled clinical trials.
- Inclusion of studies on systemic anti-fibrinolytics for traumatic hyphaema.
- Calculation of overall odds ratios using log of odds ratios and Mantel-Haenszel methods.
Main Results:
- Systemic anti-fibrinolytics demonstrated a significant beneficial effect on reducing the rate of secondary hemorrhage.
- No significant improvement in final visual acuity was observed with systemic anti-fibrinolytics.
- The analysis combined data from multiple randomized controlled trials.
Conclusions:
- Systemic anti-fibrinolytics are effective in preventing re-bleeding in traumatic hyphaema.
- Current evidence does not support the use of systemic anti-fibrinolytics for improving visual outcomes in traumatic hyphaema.
- Further investigation into visual acuity outcomes may be warranted.