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Anti-class II MHC antibodies prevent and treat EAE without APC depletion
R M Smith1, A Morgan, D C Wraith
1Department of Pathology, University of Cambridge, UK.
Immunology
|September 1, 1994
Abstract:
We have demonstrated that a murine IgG1 anti-class II major histocompatibility complex (MHC) antibody (OX6) is able both to prevent and treat experimental autoimmune encephalomyelitis (EAE) in the Biozzi AB/H mouse. We have confirmed that this antibody is poorly cytotoxic, allowing mechanisms of action other than depletion of antigen-presenting cells (APC) to be assessed. Despite its effect on disease, OX6 administration does not prevent priming of T cells in the draining lymph node, implying an alternative mechanism for regulation of the autoimmune disease process.