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Related Experiment Videos

Relationship between amniotic fluid and maternal blood nutrient levels

T Tamura1, E W Weekes, R Birch

  • 1Department of Nutrition Sciences, University of Alabama at Birmingham.

Journal of Perinatal Medicine
|January 1, 1994
PubMed
Summary

Maternal folate and vitamin B-12 levels correlate with amniotic fluid concentrations. However, amniotic fluid levels of these nutrients do not predict pregnancy outcomes like birth weight.

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Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Biochemistry
  • Maternal-Fetal Medicine

Background:

  • Maternal nutrient status is crucial for fetal development.
  • Understanding the relationship between maternal blood and amniotic fluid nutrient levels is important for monitoring pregnancy health.

Purpose of the Study:

  • To investigate the correlations between amniotic fluid and maternal blood concentrations of key nutrients (folate, vitamin B-12, zinc, copper, iron).
  • To assess if these nutrient levels relate to pregnancy outcomes.

Main Methods:

  • Simultaneous collection of amniotic fluid and maternal blood samples from 76 pregnant women at 17 weeks gestation.
  • Nutrient analysis using microbiological assay (folate), radioassay (vitamin B-12), and atomic absorption spectrophotometry (zinc, copper, iron).

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  • Statistical analysis to determine correlations between maternal and amniotic fluid levels and with pregnancy outcomes.

    • Main Results:

    • Maternal plasma and red blood cell (RBC) folate and plasma copper were higher than in non-pregnant controls.
    • Amniotic fluid concentrations of folate, zinc, copper, and iron were lower than maternal plasma levels, while vitamin B-12 was higher.
    • Significant correlations were observed between amniotic fluid and maternal blood for folate and vitamin B-12, but not for zinc, copper, or iron.
    • No correlation was found between nutrient levels and pregnancy outcomes, including infant birth weight.

    Conclusions:

    • Amniotic fluid folate and vitamin B-12 levels reflect maternal status during early pregnancy.
    • Zinc, copper, and iron levels in amniotic fluid do not correlate with maternal blood concentrations.
    • Maternal and amniotic fluid nutrient levels, as measured, do not appear to influence pregnancy outcomes like birth weight.