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Localization of protein kinase C subspecies in the rabbit retina
1Department of Biomedical Sciences, University of Tampere, Finland.
Neuroscience Letters
|August 15, 1994
Abstract:
The localization of PKC subspecies alpha, beta, gamma, epsilon and zeta was studied immunocytochemically in the rabbit retina. Conventional, Ca(2+)-sensitive PKC subtypes alpha, beta, gamma were all localized in different neuronal populations. The zeta-subspecies, which does not require Ca2+ for activation, was colocalized with PKC-alpha. PKC-epsilon, which is independent of Ca2+ and DAG, was colocalized with PKC-beta. Some populations of neurons, including cone bipolar cells, contained none of the PKC-subspecies studied. These results imply a cellular segregation of different signaling pathways in mammalian retina.