Related Experiment Videos
PD135158, a CCK-B antagonist, reduces "state," but not "trait" anxiety in mice
C Belzung1, N Pineau, A Beuzen
1Laboratoire d'Ethologie et de Psychophysiologie, UFR Sciences et Techniques, Tours, France.
Pharmacology, Biochemistry, and Behavior
|October 1, 1994
Abstract:
It has recently been proposed that Balb/c neophobic responses in a free exploratory paradigm are related to "trait" anxiety, while the behavior of mice in the light/dark choice test paradigm is related to "state" anxiety. The purpose of this study was to assess the action of the CCK-B receptor antagonist PD135158 in both models. Results show that PD135158 was effective in the light/dark choice test but not on the Balb/c neophobic reactions in the free exploratory situation. It is suggested that PD135158 is specially effective in state anxiety induced by fear provoking situations.