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Can an X-ray dose threshold be measured for the induction of SOS repair activity in E. coli
1Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
Biochemical and Biophysical Research Communications
|January 17, 1995
Abstract:
Survival ("clonogenic ability") and induced DNA repair (SOS repair) have been studied at low X-ray doses in two Escherichia coli strains (GE94 and KY943), both of which contain a recA-lacZ protein fusion. X-ray doses greater than about 0.5 Gray clearly induce SOS repair activity. However, the threshold dose that just activates SOS repair is probably much lower than 0.5 Gray, perhaps as low as 0.001 Gray. It seems unlikely that this dose threshold can be more accurately measured with the recA-lacZ fusion technique.