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Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes
A Chimirri1, R Gitto, S Grasso
1Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|October 1, 1994
Abstract:
Several 1-[(arylidene)amino]adamantanes were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell lines. Some of these derivatives showed specificity for human leukemia cell lines and 1-[(2-bromobenzylidene)amino]adamantane (2) (NSC 631076-L), the most active compound, was selected by the Biological Evaluation Committee (BEC), for in vivo testing.