Simulating the process of malignant transformation
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1Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, Washington.
Mathematical Biosciences
|October 1, 1994
Abstract:
A computationally efficient method for the simulation of carcinogenesis is presented. The underlying model for the process is the two-mutation clonal expansion model with explicit consideration of stochastic growth of malignant tumors. The usual likelihood-based methods of analysis ignore the growth kinetics of malignant tumors. The effect of this oversight on estimation of parameters is explored by simulation.