[The protein component of the epitheliocyte biopolymers in the small intestine after experimental vagotomy]

A histochemical investigation of biopolymers of the small intestine epitheliocytes after experimental vagotomy has shown that at early stages of the neurodystrophic process the most pronounced changes are noted in the distribution of amino acid residues of the proteins in the cytoplasm of epitheliocytes and in the composition of the glycoprotein secretion of goblet exocrinocytes. The undulatory changes might be accounted for by activation of the function of cholinergic nerve fibers coming via the sympathetic nerves against the background of vagus denervation. The changes in protein-containing biopolymers suggest deep disturbances in conditions of denervation. The primary changes might be a result of posttranslational transformations of the biopolymer complex molecules, while the later ones is a disturbance of the process of biosynthetic activity of the cells. It can't be excluded that the changes found might be a cause of postvagotomy diarrhea, often complicating the postoperative period in ulcer patients.