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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining
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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

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Antibiotic susceptibility pattern of gonococcal isolates

S K Jain1, M G Kulkarni, D D Banker

  • 1Sir H. N. Hospital, Bombay.

Indian Journal of Medical Sciences
|October 1, 1994
PubMed

Insights

Antibiotic resistance in Neisseria gonorrhoeae is a growing concern. This study found that while penicillin and gentamicin resistance is significant, fluoroquinolones like norfloxacin and ciprofloxacin remain effective against gonococcal urethritis isolates.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Neisseria gonorrhoeae causes gonococcal urethritis, a common sexually transmitted infection.
  • Increasing antibiotic resistance poses a significant public health threat, complicating treatment.
  • Understanding local antibiotic susceptibility patterns is crucial for effective management.

Purpose of the Study:

  • To determine the antibiotic susceptibility patterns of Neisseria gonorrhoeae isolates from patients with gonococcal urethritis.
  • To assess the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG).
  • To evaluate the efficacy of commonly used antibiotics, including penicillin, gentamicin, and fluoroquinolones.

Main Methods:

  • A total of 151 isolates of Neisseria gonorrhoeae were collected from patients with gonococcal urethritis.
  • Antibiotic susceptibility testing was performed using the single disc diffusion technique.
  • Isolates were tested against penicillin, gentamicin, norfloxacin, and ciprofloxacin.

Main Results:

  • 17.88% of the isolates were identified as penicillinase-producing Neisseria gonorrhoeae (PPNG).
  • Susceptibility to penicillin was observed in only 82.12% of isolates.
  • Gentamicin susceptibility was found in 94.04% of isolates.
  • All tested isolates demonstrated sensitivity to fluoroquinolones, specifically norfloxacin and ciprofloxacin.

Conclusions:

  • A significant proportion of Neisseria gonorrhoeae isolates exhibit resistance to penicillin, highlighting the need for alternative treatments.
  • While gentamicin shows good susceptibility, fluoroquinolones (norfloxacin and ciprofloxacin) are currently highly effective against local Neisseria gonorrhoeae strains.
  • Continuous monitoring of antibiotic resistance patterns is essential for guiding gonococcal urethritis treatment strategies.

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