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Related Experiment Video

Updated: May 19, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

Antibiotic susceptibility pattern of gonococcal isolates

S K Jain¹, M G Kulkarni, D D Banker

¹Sir H. N. Hospital, Bombay.

Indian Journal of Medical Sciences

|October 1, 1994

Summary

Antibiotic resistance in Neisseria gonorrhoeae is a growing concern. This study found that while penicillin and gentamicin resistance is significant, fluoroquinolones like norfloxacin and ciprofloxacin remain effective against gonococcal urethritis isolates.

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

Microbiology
Infectious Diseases
Antimicrobial Resistance

Background:

Neisseria gonorrhoeae causes gonococcal urethritis, a common sexually transmitted infection.
Increasing antibiotic resistance poses a significant public health threat, complicating treatment.
Understanding local antibiotic susceptibility patterns is crucial for effective management.

Purpose of the Study:

To determine the antibiotic susceptibility patterns of Neisseria gonorrhoeae isolates from patients with gonococcal urethritis.
To assess the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG).
To evaluate the efficacy of commonly used antibiotics, including penicillin, gentamicin, and fluoroquinolones.

Main Methods:

A total of 151 isolates of Neisseria gonorrhoeae were collected from patients with gonococcal urethritis.
Antibiotic susceptibility testing was performed using the single disc diffusion technique.
Isolates were tested against penicillin, gentamicin, norfloxacin, and ciprofloxacin.

Main Results:

17.88% of the isolates were identified as penicillinase-producing Neisseria gonorrhoeae (PPNG).
Susceptibility to penicillin was observed in only 82.12% of isolates.
Gentamicin susceptibility was found in 94.04% of isolates.
All tested isolates demonstrated sensitivity to fluoroquinolones, specifically norfloxacin and ciprofloxacin.

Conclusions:

A significant proportion of Neisseria gonorrhoeae isolates exhibit resistance to penicillin, highlighting the need for alternative treatments.
While gentamicin shows good susceptibility, fluoroquinolones (norfloxacin and ciprofloxacin) are currently highly effective against local Neisseria gonorrhoeae strains.
Continuous monitoring of antibiotic resistance patterns is essential for guiding gonococcal urethritis treatment strategies.