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Bacteriostatic and bactericidal activities of paromomycin against Mycobacterium avium complex isolates
C Piersimoni1, S Bornigia, G De Sio
1Department of Clinical Microbiology, General Hospital Umberto I., Torrette, Ancona, Italy.
The Journal of Antimicrobial Chemotherapy
|September 1, 1994
Abstract:
The MICs and MBCs of paromomycin for 32 Mycobacterium avium complex (MAC) strains isolated from patients with the acquired immunodeficiency syndrome were determined by a radiometric broth dilution method. The MICs for the majority of strains were either 8 or 16 mg/L and the MBCs were four- to eight-fold higher. Paromomycin merits further evaluation as oral prophylaxis against disseminated MAC infection.