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Related Experiment Videos

Endocrine and cytokine changes during elective surgery

M L Wellby1, J A Kennedy, P B Barreau

  • 1Department of Clinical Chemistry, Queen Elizabeth Hospital, Woodville, Adelaide, South Australia.

Journal of Clinical Pathology
|November 1, 1994
PubMed
Summary
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Severe surgery, a model for non-thyroidal illness, showed early thyroid hormone changes precede interleukin-6 increases. This suggests interleukin-6 does not cause the initial decrease in thyroid hormones following trauma.

Area of Science:

  • Endocrinology
  • Surgical Physiology

Background:

  • Severe non-thyroidal illness (SNTI) is associated with altered thyroid hormone levels.
  • The role of inflammatory markers like interleukin-6 (IL-6) in these changes is not fully understood.

Purpose of the Study:

  • To investigate the relationship between serum thyroid hormones, thyroid stimulating hormone (TSH), cortisol, and IL-6 concentrations following elective surgery.
  • To determine if IL-6 increase is the cause of decreased tri-iodothyronine (T3) after severe trauma.

Main Methods:

  • Abdominal surgery under general anesthesia served as a model for SNTI.
  • Blood samples were collected from 11 patients for 24 hours pre-operatively and 48 hours post-operatively.
  • Measurements included total T3, free T3, free thyroxine (T4), TSH, cortisol, and IL-6.

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Main Results:

  • Total T3 decreased early post-surgery. Free T3 also decreased after a transient rise. Free T4 levels remained unchanged.
  • TSH increased at 4 hours, with suppressed nocturnal surge. Cortisol peaked at 4 hours.
  • IL-6 increase was observed at 4 hours post-surgery, later than hormonal changes.

Conclusions:

  • Early alterations in thyroid hormones and TSH after surgery do not appear to be triggered by IL-6.
  • The study provides insights into the complex endocrine response to surgical stress and SNTI.