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Emergence of multi-drug resistance among beta-lactamase producing Salmonella
Abstract:
Multi-drug resistant strains of Salmonella isolated from blood and bone marrow cultures of pyrexial patients received from physicians, hospitals and different clinics were studied from May to November, 1993. Of 2143 samples collected, 424(20%) cases yielded the growth of different organisms. Out of these 266(63%) were positive for Salmonella strains. The strains isolated were Salmonella typhi 239(90%) and Salmonella paratyphi A 27(10%). Two hundred twenty (82%) strains of Salmonella showed increased beta-lactamase activity and an alarming increase in resistance against commonly used antibiotics for enteric fever.
Insights
Multi-drug resistant Salmonella strains, including Salmonella typhi and Salmonella paratyphi A, were identified in patient cultures. A significant increase in beta-lactamase activity and antibiotic resistance poses a challenge for treating enteric fever.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Enteric fever, primarily caused by Salmonella species, remains a significant global health concern.
- The emergence of multi-drug resistant (MDR) Salmonella strains complicates treatment strategies.
- Pyrexial patients presenting with suspected bloodstream infections are often tested for Salmonella.
Purpose of the Study:
- To investigate the prevalence of multi-drug resistant Salmonella strains in clinical samples.
- To identify the specific Salmonella serotypes involved and assess their antibiotic resistance patterns.
- To determine the extent of beta-lactamase activity among isolated Salmonella strains.
Main Methods:
- Collection and culture of blood and bone marrow samples from pyrexial patients.
- Identification of Salmonella strains using standard microbiological techniques.
- Antimicrobial susceptibility testing and assessment of beta-lactamase activity.
Main Results:
- Out of 2143 samples, 424 (20%) yielded microbial growth, with 266 (63%) positive for Salmonella.
- Salmonella typhi accounted for 90% (239 strains) and Salmonella paratyphi A for 10% (27 strains).
- A high proportion (82%, 220 strains) of Salmonella isolates exhibited increased beta-lactamase activity and resistance to common enteric fever antibiotics.
Conclusions:
- The study highlights a significant prevalence of MDR Salmonella typhi and Salmonella paratyphi A in clinical settings.
- Elevated beta-lactamase activity is a key mechanism contributing to antibiotic resistance in these strains.
- Urgent strategies are needed to combat the rising antimicrobial resistance in Salmonella to ensure effective treatment of enteric fever.