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Related Experiment Videos

Effect of reversed intestinal segments on intestinal structure and function

J S Thompson1, E M Quigley, T E Adrian

  • 1Surgical Service, Omaha VAMC, Nebraska.

The Journal of Surgical Research
|January 1, 1995
PubMed
Summary

Reversing a segment of the intestine after resection impaired adaptation and nutritional status in dogs. Intestinal function, including motility and absorption, was negatively impacted by this surgical modification.

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Area of Science:

  • Gastroenterology
  • Surgical Innovation
  • Intestinal Physiology

Background:

  • Intestinal resection necessitates adaptation for nutrient absorption and function.
  • Surgical techniques aim to optimize post-resection intestinal adaptation.
  • The effect of segment reversal on intestinal adaptation requires further investigation.

Purpose of the Study:

  • To evaluate the short-term effects of a reversed intestinal segment on structural and functional adaptation following distal resection.
  • To compare the nutritional status, absorption, motility, and hormonal response in dogs with and without intestinal segment reversal.

Main Methods:

  • Ten dogs underwent 75% distal intestinal resection.
  • Five dogs had a reversed terminal segment (RS group), while five had a standard remnant (RO group).

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  • Nutritional status, absorption, motility, hormonal response, and remnant adaptation were assessed at 4, 8, and 12 weeks.

    • Main Results:

    • Both groups experienced weight loss, with greater loss in the RS group.
    • Hypoalbuminemia and reduced caloric intake were observed in the RS group.
    • Intestinal remnant length increased in the RO group but not the RS group; altered myoelectrical activity was noted in the reversed segment.

    Conclusions:

    • Reversing a segment of the intestine after resection negatively impacts nutritional status and intestinal adaptation.
    • The reversed segment exhibits abnormal myoelectrical activity, hindering normal intestinal function.
    • Segment reversal is not beneficial and may be detrimental for short-term intestinal adaptation after resection.