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[Fixed pigmented erythema caused by levamisole administration]

P Clavère1, A Bonnafoux-Clavère, J L Delrous

  • 1Service de Radiothérapie et de Carcinologie, CHRU Dupuytren, Limoges.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
Summary

Levamisole, an adjuvant in chemotherapy, can cause fixed drug eruptions. This case highlights fixed pigmented erythema as a potential adverse reaction to levamisole.

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Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • This report details a case of fixed drug eruption.
  • Levamisole is often used as an adjuvant in chemotherapy regimens.

Observation:

  • A patient undergoing chemotherapy for colon cancer developed fixed toxic erythema with pigmentation.
  • The patient was taking levamisole in combination with 5-fluorouracil.
  • Epicutaneous skin tests for levamisole were negative.

Findings:

  • Levamisole was highly likely responsible for the observed fixed drug eruption.
  • The adverse reaction presented as fixed pigmented erythema.

Implications:

  • This case suggests that levamisole can induce fixed pigmented erythema.

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  • Fixed pigmented erythema should be recognized as a potential side effect of levamisole treatment.
  • Dermatologists and oncologists should be aware of this association when prescribing levamisole.