[Disulone hypersensitivity syndrome]

Area of Science:

• Dermatology
• Pharmacology
• Hepatology

Background:

• Hypersensitivity to dapsone (Disulone) is a rare but serious adverse effect of sulfone therapy.
• Diagnosis involves clinical signs like hyperthermia, skin eruptions, and hepatitis.
• Dapsone is used to treat various conditions, including autoimmune bullous dermatoses.

Observation:

• A 57-year-old woman developed a hypersensitivity reaction while treated with dapsone for cicatricial pemphigoid.
• The patient presented with hyperthermia and hepatitis.
• Notably, the classical skin eruptions associated with dapsone hypersensitivity were absent in this case.

Findings:

• The patient's clinical manifestations and laboratory results normalized within three weeks of discontinuing dapsone.
• This case represents a variant presentation of dapsone hypersensitivity syndrome.
• The absence of skin lesions is a key distinguishing feature.

Implications:

• This case expands the known clinical spectrum of dapsone hypersensitivity.
• It underscores the importance of considering dapsone hypersensitivity even in the absence of typical skin manifestations.
• Further research may be needed to understand the varied presentations of drug hypersensitivity syndromes in autoimmune diseases.