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[Disulone hypersensitivity syndrome]

L Risse1, P Bernard, A Brosset

  • 1Service de Dermato-Vénéréologie, CHRU Dupuytren, Limoges.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
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Hypersensitivity to dapsone, a rare sulfone therapy side effect, can manifest with fever and hepatitis, but typically not skin issues. This case highlights a unique presentation during autoimmune bullous dermatosis treatment.

Area of Science:

  • Dermatology
  • Pharmacology
  • Hepatology

Background:

  • Hypersensitivity to dapsone (Disulone) is a rare but serious adverse effect of sulfone therapy.
  • Diagnosis involves clinical signs like hyperthermia, skin eruptions, and hepatitis.
  • Dapsone is used to treat various conditions, including autoimmune bullous dermatoses.

Observation:

  • A 57-year-old woman developed a hypersensitivity reaction while treated with dapsone for cicatricial pemphigoid.
  • The patient presented with hyperthermia and hepatitis.
  • Notably, the classical skin eruptions associated with dapsone hypersensitivity were absent in this case.

Findings:

  • The patient's clinical manifestations and laboratory results normalized within three weeks of discontinuing dapsone.

Related Experiment Videos

  • This case represents a variant presentation of dapsone hypersensitivity syndrome.
  • The absence of skin lesions is a key distinguishing feature.

    • Implications:

    • This case expands the known clinical spectrum of dapsone hypersensitivity.
    • It underscores the importance of considering dapsone hypersensitivity even in the absence of typical skin manifestations.
    • Further research may be needed to understand the varied presentations of drug hypersensitivity syndromes in autoimmune diseases.