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Melkersson-Rosenthal syndrome
H A Cohen1, Z Cohen, A Ashkenasi
1Department of Pediatrics, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
Insights
Melkersson-Rosenthal syndrome, a rare condition causing facial swelling and nerve issues, was diagnosed in four pediatric patients. Follow-up evaluations and literature review offer insights into this uncommon disorder in children.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Melkersson-Rosenthal syndrome (MRS) is a rare neurological disorder characterized by facial swelling, lip edema, and facial palsy.
- While typically diagnosed in adults, pediatric cases present unique diagnostic and management challenges.
Observation:
- Four pediatric patients presented with recurrent upper lip and facial swelling, lingua plicata (folded tongue), and peripheral facial nerve palsy.
- These symptoms collectively indicated a diagnosis of Melkersson-Rosenthal syndrome.
Findings:
- The study details the follow-up evaluations of these four pediatric patients.
- Literature review was conducted to compare findings with existing pediatric MRS cases, highlighting the syndrome's rarity in this demographic.
Implications:
- Understanding the clinical course and management of pediatric MRS is crucial for early diagnosis and intervention.
- Further research into the genetic and environmental factors contributing to pediatric MRS may improve patient outcomes.
Abstract:
Four patients with recurrent upper lip and facial swelling and lingua plicata together with peripheral facial nerve palsy involvement were diagnosed as having Melkersson-Rosenthal syndrome. Because of the rarity of this syndrome in children, we present the results of follow-up evaluations of our patients and review the literature.