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Decrease in vitamin E levels in the bone marrow of mice receiving whole-body X-ray irradiation

K Umegaki1, T Ichikawa

  • 1Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan.

Free Radical Biology & Medicine
|November 1, 1994
PubMed
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Whole-body x-ray irradiation significantly depletes vitamin E and increases lipid peroxides in mouse bone marrow, indicating high susceptibility to radiation-induced oxidative damage.

Area of Science:

  • Radiation Biology
  • Biochemistry
  • Toxicology

Background:

  • X-ray irradiation is known to induce oxidative stress in biological systems.
  • Vitamin E is a key antioxidant, and lipid peroxides are markers of oxidative damage.

Purpose of the Study:

  • To investigate the effects of whole-body x-ray irradiation on vitamin E and lipid peroxide levels in various mouse tissues.
  • To determine the susceptibility of different tissues to radiation-induced oxidative damage.

Main Methods:

  • Mice were subjected to whole-body x-ray irradiation with doses ranging from 1 to 10 Gy.
  • Vitamin E content, lipid peroxide levels, and glutathione concentrations were measured in bone marrow, liver, kidney, spleen, and testes.

Main Results:

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  • Bone marrow showed a dose-dependent decrease in vitamin E and a concomitant increase in lipid peroxides starting 3 hours post-irradiation (6 Gy).
  • Significant changes in bone marrow were observed with doses of 3 Gy or more.
  • Liver, kidney, spleen, and testes did not exhibit significant changes in vitamin E or lipid peroxides even at 10 Gy.
  • Glutathione levels decreased in bone marrow but increased in the liver post-irradiation.

Conclusions:

  • The bone marrow is highly susceptible to radiation-induced oxidative damage compared to other examined tissues.
  • Vitamin E depletion and lipid peroxidation are key indicators of oxidative stress in the bone marrow following irradiation.