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Related Experiment Videos

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

M G Baxter1, T H Lanthorn, K M Frick

  • 1Department of Psychology, Johns Hopkins University, Baltimore, MD 21218.

Neurobiology of Aging
|March 1, 1994
PubMed
Summary

D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. This study found D-cycloserine improved cognitive deficits in aged rats, suggesting potential for treating cognitive impairment disorders.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Aging Research

Background:

  • Cognitive deficits are a hallmark of aging.
  • D-cycloserine is a partial agonist of the NMDA receptor-associated glycine site.
  • NMDA receptor modulation is a potential target for cognitive enhancement.

Purpose of the Study:

  • To investigate the behavioral effects of D-cycloserine on cognitive deficits in aged Fischer-344 rats.
  • To determine if D-cycloserine can improve performance in tasks related to learning and memory.
  • To assess the impact of D-cycloserine on sensorimotor function in aged rats.

Main Methods:

  • Aged male Fischer-344 rats (24 months old) were administered vehicle or one of three doses of D-cycloserine.
  • Younger rats (4 months old) received vehicle as a control.

Related Experiment Videos

  • Cognitive performance was assessed using place discrimination and repeated acquisition tasks in a water maze.
  • Sensorimotor function was evaluated using a variety of tasks.

    • Main Results:

    • Aging significantly impaired performance across all tested tasks.
    • D-cycloserine administration dose-dependently improved performance in both place discrimination and repeated acquisition tasks.
    • No significant effects of D-cycloserine were observed on sensorimotor functions.
    • Aged rats showed cognitive deficits that were ameliorated by D-cycloserine.

    Conclusions:

    • D-cycloserine demonstrates cognition-enhancing properties in aged rats.
    • The findings support the potential therapeutic utility of D-cycloserine for cognitive impairment disorders.
    • NMDA receptor modulation via D-cycloserine may offer a strategy to combat age-related cognitive decline.